Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735962
Species: Homo sapiens
RGD Object: Gene
Symbol: APOA1
Name: apolipoprotein A1
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APOA1decreases expressionEXP 6480464CTDFenofibrate results in decreased expression of APOA1 mRNA; Fenofibrate results in decreased expression of APOA1 proteinPMID:19445040 PMID:7983038
APOA1multiple interactionsEXP 6480464CTDFenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]; PPARA protein inhibits the reaction [Fenofibrate results in decreased expression of APOA1 mRNA]PMID:19201410 PMID:7983038
APOA1multiple interactionsISOApoa1 (Mus musculus)6480464CTDFenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]; PPARA protein affects the reaction [Fenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]]PMID:19201410
APOA1multiple interactionsISOApoa1 (Rattus norvegicus)6480464CTD[Fenofibrate co-treated with Pyrazinamide] results in increased expression of APOA1 mRNAPMID:27071702
Go Back to source page   Continue to Ontology report