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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735883
Species: Homo sapiens
RGD Object: Gene
Symbol: IL17A
Name: interleukin 17A
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL17Aincreases expressionEXP 6480464CTDParaquat results in increased expression of IL17A proteinPMID:36108500
IL17Aincreases expressionISOIl17a (Mus musculus)6480464CTDParaquat results in increased expression of IL17A mRNA; Paraquat results in increased expression of IL17A proteinPMID:28600744 PMID:36108500
IL17Amultiple interactionsISOIl17a (Mus musculus)6480464CTDIL17A protein promotes the reaction [Paraquat results in increased expression of and affects the localization of RELA protein]; IL17A protein promotes the reaction [Paraquat results in increased expression of IL17A mRNA]; IL17A protein promotes the reaction [Paraquat results in increased expression of IL6 protein]; IL17A protein promotes the reaction [Paraquat results in increased expression of TNF protein]PMID:28600744
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