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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735879
Species: Mus musculus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Achedecreases activityEXP 6480464CTDbisphenol A results in decreased activity of ACHE proteinPMID:23871786 PMID:34655688
Achedecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ACHE mRNAPMID:32156529
Acheincreases expressionEXP 6480464CTDbisphenol A results in increased expression of ACHE mRNA; bisphenol A results in increased expression of ACHE mRNA alternative formPMID:34655688
Achemultiple interactionsEXP 6480464CTDHDAC2 protein affects the reaction [bisphenol A results in increased expression of ACHE mRNA alternative form]; HDAC2 protein affects the reaction [bisphenol A results in increased expression of ACHE mRNA]PMID:34655688
Achedecreases expressionISOAche (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of ACHE mRNAPMID:25181051 PMID:30816183 PMID:32528016 PMID:34947998
Acheincreases activityISOAche (Rattus norvegicus)6480464CTDbisphenol A results in increased activity of ACHE proteinPMID:32172062 PMID:32701268 PMID:32810514
Acheincreases activityISOACHE (Homo sapiens)6480464CTDbisphenol A results in increased activity of ACHE proteinPMID:29079494
Acheincreases expressionISOAche (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of ACHE proteinPMID:32428650
Acheincreases expressionISOACHE (Homo sapiens)6480464CTDbisphenol A results in increased expression of ACHE mRNA; bisphenol A results in increased expression of ACHE proteinPMID:30238673
Acheincreases methylationISOACHE (Homo sapiens)6480464CTDbisphenol A results in increased methylation of ACHE genePMID:28582417
Achemultiple interactionsISOAche (Rattus norvegicus)6480464CTD[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ACHE protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of ACHE protein]PMID:32172062 PMID:32428650 PMID:32810514
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