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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735879
Species: Mus musculus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:28741
Term: sodium fluoride
Definition: A metal fluoride salt with a Na(+) counterion.
Chemical ID: MESH:D012969
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Achedecreases expressionEXP 6480464CTDSodium Fluoride results in decreased expression of ACHE mRNA; Sodium Fluoride results in decreased expression of ACHE proteinPMID:27862939 PMID:36286330
Acheincreases activityEXP 6480464CTDSodium Fluoride results in increased activity of ACHE proteinPMID:19635623
Achemultiple interactionsEXP 6480464CTDCholine inhibits the reaction [Sodium Fluoride results in decreased expression of ACHE protein]; sodium arsenite promotes the reaction [Sodium Fluoride results in increased activity of ACHE protein]PMID:19635623 PMID:36286330
Acheaffects activityISOAche (Rattus norvegicus)6480464CTDSodium Fluoride affects the activity of ACHE proteinPMID:36228752
Achedecreases activityISOAche (Rattus norvegicus)6480464CTDSodium Fluoride results in decreased activity of ACHE proteinPMID:27840156 PMID:31710167
Achemultiple interactionsISOAche (Rattus norvegicus)6480464CTD[2,2-bis(4-glycidyloxyphenyl)propane co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; [[sodium arsenite results in increased abundance of Arsenic] co-treated with [Sodium Fluoride results in increased abundance of Fluorides]] results in decreased activity of ACHE protein; [Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein; Clofibrate inhibits the reaction [Sodium Fluoride results in decreased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Lisinopril inhibits the reaction [Sodium Fluoride results in decreased activity of ACHE protein]; Taurine inhibits the reaction [Sodium Fluoride results in decreased activity of ACHE protein]PMID:27840156 PMID:31710167 PMID:32627286 PMID:33609566
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