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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735879
Species: Mus musculus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Achedecreases activityEXP 6480464CTDRotenone results in decreased activity of ACHE proteinPMID:31714633
Acheincreases expressionEXP 6480464CTDRotenone results in increased expression of ACHE proteinPMID:31820278
Achemultiple interactionsEXP 6480464CTD[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; carbidopa, levodopa drug combination inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Niacin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; ZM 241385 inhibits the reaction [Rotenone results in increased expression of ACHE protein]PMID:31714633 PMID:31820278
Achedecreases activityISOAche (Rattus norvegicus)6480464CTDRotenone results in decreased activity of ACHE proteinPMID:35187747 PMID:35337893
Acheincreases activityISOAche (Rattus norvegicus)6480464CTDRotenone results in increased activity of ACHE proteinPMID:28389404 PMID:36965781
Achemultiple interactionsISOAche (Rattus norvegicus)6480464CTDApigenin inhibits the reaction [Rotenone results in increased activity of ACHE protein]; Catechin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Quercetin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; taxifolin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; vinpocetine inhibits the reaction [Rotenone results in increased activity of ACHE protein]PMID:28389404 PMID:35187747 PMID:35337893 PMID:36965781
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