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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735878
Species: Homo sapiens
RGD Object: Gene
Symbol: ACHE
Name: acetylcholinesterase (Yt blood group)
Acc ID: CHEBI:64312
Term: memantine
Definition: A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Chemical ID: MESH:D008559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACHEdecreases activityISOAche (Rattus norvegicus)6480464CTDMemantine results in decreased activity of ACHE proteinPMID:30588862
ACHEmultiple interactionsISOAche (Rattus norvegicus)6480464CTDasoxime chloride inhibits the reaction [Memantine inhibits the reaction [Soman results in decreased activity of ACHE protein]]; Memantine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Memantine inhibits the reaction [Soman results in decreased activity of ACHE protein]PMID:2241428 PMID:30682440
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