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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDSB 203580 results in decreased expression of NQO1 mRNA

PMID:27454768
multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [Particulate Matter analog results in increased expression of NQO1 mRNA], SB 203580 inhibits the reaction [Particulate Matter analog results in increased expression of NQO1 protein], SB 203580 inhibits the reaction [Plant Extracts results in increased expression of NQO1 protein], SB 203580 inhibits the reaction [Quercetin results in increased expression of NQO1 mRNA], SB 203580 inhibits the reaction [Vehicle Emissions analog results in increased expression of NQO1 mRNA], SB 203580 inhibits the reaction [Vehicle Emissions analog results in increased expression of NQO1 protein]

PMID:16920990, PMID:27454768, PMID:30626086
multiple interactionsISORGD:104736480464CTDSB 203580 inhibits the reaction [2', 4'-dihydroxy-6'-methoxy-3', 5'-dimethylchalcone results in increased expression of NQO1 mRNA], SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of NQO1 mRNA], SB 203580 promotes the reaction [Copper results in increased expression of NQO1 mRNA], SB 203580 promotes the reaction [Lead results in increased expression of NQO1 mRNA]

PMID:18752316, PMID:28329830, PMID:31029725
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.