Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:77149
Term: notoginsenoside R1
Definition: A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.
Chemical ID: MESH:C072936
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:25036480464CTDnotoginsenoside R1 results in increased expression of NQO1 protein

PMID:24437944
multiple interactionsISORGD:25036480464CTDCycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein], Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein], fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein], NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of NQO1 protein], notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of NQO1 protein]

PMID:24437944
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.