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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDMetformin results in decreased expression of NQO1 protein

PMID:23707609
multiple interactionsEXP 6480464CTDMetformin inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of and results in increased activity of NQO1 protein], Metformin inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of NQO1 mRNA]

PMID:25697376
decreases expressionISORGD:25036480464CTDMetformin results in decreased expression of NQO1 mRNA

PMID:21457706
increases expressionISORGD:25036480464CTDMetformin results in increased expression of NQO1 mRNA

PMID:25596134
multiple interactionsISORGD:25036480464CTDMetformin inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA], Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 mRNA]

PMID:21457706, PMID:22666520
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.