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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:65585
Term: carnosic acid
Definition: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.
Chemical ID: MESH:C018381
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDsalvin results in increased expression of NQO1 protein

PMID:26686574
multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of NQO1 protein], NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein], salvin inhibits the reaction [Acrylamide results in decreased expression of NQO1 mRNA]

PMID:26686574, PMID:28159594
increases expressionISORGD:104736480464CTDsalvin results in increased expression of NQO1 mRNA

PMID:18329808
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.