GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NQO1 | decreases expression | EXP | | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA; 1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein | PMID:30965670 | NQO1 | increases expression | EXP | | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in increased expression of NQO1 mRNA; 1-Methyl-4-phenylpyridinium results in increased expression of NQO1 protein | PMID:24810058 PMID:30965670 | NQO1 | multiple interactions | EXP | | 6480464 | CTD | NFE2L2 protein promotes the reaction [Pioglitazone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]]; NFE2L2 protein promotes the reaction [Pioglitazone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]]; Pioglitazone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]; Pioglitazone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]; Pioglitazone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NQO1 mRNA]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NQO1 mRNA] | PMID:30965670 | NQO1 | affects expression | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein | PMID:33645131 | NQO1 | decreases activity | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein | PMID:22019741 | NQO1 | increases expression | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in increased expression of NQO1 mRNA | PMID:28801915 | NQO1 | multiple interactions | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein] | PMID:22019741 PMID:33645131 | | ||||||||||||||||||||||
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