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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:51348
Term: tetraphene
Definition: An angular ortho-fused polycyclic arene consisting of four fused benzene rings.
Chemical ID: MESH:C030935
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NQO1increases activityEXP 6480464CTDbenz(a)anthracene results in increased activity of NQO1 proteinPMID:9029048
NQO1increases expressionEXP 6480464CTDbenz(a)anthracene results in increased expression of NQO1 mRNAPMID:17253728 PMID:9029048
NQO1increases activityISONqo1 (Rattus norvegicus)6480464CTDbenz(a)anthracene results in increased activity of NQO1 proteinPMID:7587946
NQO1increases expressionISONqo1 (Rattus norvegicus)6480464CTDbenz(a)anthracene results in increased expression of NQO1 mRNAPMID:7587946
NQO1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTD1-(5-isoquinolinylsulfonyl)-3-methylpiperazine inhibits the reaction [benz(a)anthracene results in increased activity of NQO1 protein]; Dexamethasone inhibits the reaction [benz(a)anthracene results in increased activity of NQO1 protein]; Dexamethasone inhibits the reaction [benz(a)anthracene results in increased expression of NQO1 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [benz(a)anthracene results in increased activity of NQO1 protein]]; Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of NQO1 protein]PMID:7587946
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