Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of NQO1 mRNA, Acetaminophen results in decreased expression of NQO1 protein

PMID:29067470, PMID:29136249
increases activityEXP 6480464CTDAcetaminophen results in increased activity of NQO1 protein

PMID:16610002
increases expressionEXP 6480464CTDAcetaminophen results in increased expression of NQO1, Acetaminophen results in increased expression of NQO1 mRNA, Acetaminophen results in increased expression of NQO1 protein

PMID:16610002, PMID:21420995, PMID:24631341
multiple interactionsEXP 6480464CTDChlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA], Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 protein]

PMID:29136249
affects expressionISORGD:104736480464CTDAcetaminophen affects the expression of NQO1 mRNA

PMID:17562736
decreases activityISORGD:25036480464CTDAcetaminophen results in decreased activity of NQO1 protein

PMID:26767949
decreases expressionISORGD:25036480464CTDAcetaminophen results in decreased expression of NQO1 mRNA, Acetaminophen results in decreased expression of NQO1 protein

PMID:26767949
increases expressionISORGD:104736480464CTDAcetaminophen results in increased expression of NQO1 mRNA, Acetaminophen results in increased expression of NQO1 protein

PMID:12540782, PMID:15496496, PMID:17935745, PMID:19371629, PMID:20100502, PMID:26452297, PMID:29246445, PMID:29355602
increases expressionISORGD:25036480464CTDAcetaminophen results in increased expression of NQO1 mRNA

PMID:15120968, PMID:15976192, PMID:17202759, PMID:17202762, PMID:25242409, PMID:30723492
increases response to substanceISORGD:104736480464CTDNQO1 gene mutant form results in increased susceptibility to Acetaminophen

PMID:25224400
multiple interactionsISORGD:104736480464CTD[NQO1 gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of AIFM1 protein, [NQO1 gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of DIABLO protein, [NQO1 gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ENDOG protein, [sodium boranocarbonate co-treated with Acetaminophen] results in increased expression of NQO1 mRNA, Acetaminophen promotes the reaction [1-(2-cyano-3, 12-dioxooleana-1, 9-dien-28-oyl) imidazole results in increased expression of NQO1 mRNA], Acetaminophen promotes the reaction [Tobacco Smoke Pollution results in increased expression of NQO1 mRNA], andrographolide promotes the reaction [Acetaminophen results in increased expression of NQO1 mRNA], NFE2L2 protein affects the reaction [[Acetaminophen co-treated with 1-(2-cyano-3, 12-dioxooleana-1, 9-dien-28-oyl) imidazole] results in increased expression of NQO1 mRNA], NFE2L2 protein affects the reaction [Acetaminophen results in increased expression of NQO1 mRNA], NFE2L2 protein affects the reaction [Acetaminophen results in increased expression of NQO1 protein], O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1, 2-diolate inhibits the reaction [Acetaminophen results in increased expression of NQO1 mRNA], PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of NQO1 mRNA], Tobacco Smoke Pollution promotes the reaction [Acetaminophen results in increased expression of NQO1 mRNA]

PMID:12540782, PMID:17935745, PMID:19371629, PMID:25224400, PMID:26452297, PMID:29246445, PMID:29355602, PMID:30273691
multiple interactionsISORGD:25036480464CTDmorin inhibits the reaction [Acetaminophen results in decreased activity of NQO1 protein], morin inhibits the reaction [Acetaminophen results in decreased expression of NQO1 protein]

PMID:26767949
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.