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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:44409
Term: NADP zwitterion
Definition: A NADP that has formula 743.40528.
Chemical ID: MESH:D009249
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone], [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone, [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone, [NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone, [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone, [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of 9, 10-phenanthrenequinone, [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-1, 6-quinone, [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-3, 6-quinone, [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7, 8-dione, [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of Chrysenes, [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of Dihydroxydihydrobenzopyrenes, [NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of Naphthalenes

PMID:20545351, PMID:21910479
multiple interactionsISORGD:25036480464CTDNADP promotes the reaction [NQO1 protein results in increased reduction of Vitamin K 3]

PMID:27558805
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.