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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:41977
Term: daunorubicin
Definition: A natural product found in Actinomadura roseola.
Chemical ID: MESH:D003630
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NQO1decreases expressionEXP 6480464CTDDaunorubicin results in decreased expression of NQO1 mRNA; Daunorubicin results in decreased expression of NQO1 proteinPMID:22021338
NQO1increases activityISONqo1 (Rattus norvegicus)6480464CTDDaunorubicin results in increased activity of NQO1 proteinPMID:3986001 PMID:8875677 PMID:9620540
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