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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:41039
Term: benfotiamine
Definition: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Chemical ID: MESH:C013835
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:104736480464CTDbenphothiamine metabolite results in increased expression of NQO1 mRNA, benphothiamine results in increased expression of NQO1 mRNA

PMID:29860433
multiple interactionsISORGD:104736480464CTD[benphothiamine co-treated with MAPT protein] results in increased expression of NQO1 mRNA, NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of NQO1 mRNA], NFE2L2 protein affects the reaction [benphothiamine results in increased expression of NQO1 mRNA]

PMID:29860433
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.