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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:40618
Term: aminoguanidine
Definition: A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Chemical ID: MESH:C004479
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:104736480464CTDpimagedine inhibits the reaction [Spermidine results in increased activity of NQO1 protein], pimagedine inhibits the reaction [Spermidine results in increased expression of NQO1 mRNA], pimagedine inhibits the reaction [Spermine results in increased activity of NQO1 protein]

PMID:12763045
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.