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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTetradecanoylphorbol Acetate results in increased expression of NQO1 mRNA

PMID:24632381
multiple interactionsEXP 6480464CTD2-tert-butylhydroquinone promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of NQO1 mRNA], [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NQO1 mRNA, Arsenicals promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of NQO1 mRNA]

PMID:16979875, PMID:24632381
multiple interactionsISORGD:104736480464CTDTetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of NQO1 mRNA], Tetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of NQO1 protein], Tetradecanoylphorbol Acetate inhibits the reaction [Lead results in increased expression of NQO1 mRNA], Tetradecanoylphorbol Acetate inhibits the reaction [Lead results in increased expression of NQO1 protein], Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 mRNA], Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 protein]

PMID:18752316
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.