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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NQO1increases expressionEXP 6480464CTDMethylcholanthrene results in increased expression of NQO1 mRNAPMID:17253728
NQO1increases activityISONqo1 (Mus musculus)6480464CTDMethylcholanthrene results in increased activity of NQO1 proteinPMID:15337587
NQO1increases activityISONqo1 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased activity of NQO1 proteinPMID:12206817 PMID:15302093 PMID:16906435 PMID:4005852
NQO1increases expressionISONqo1 (Mus musculus)6480464CTDMethylcholanthrene results in increased expression of NQO1 mRNA; Methylcholanthrene results in increased expression of NQO1 proteinPMID:15337587 PMID:20713471 PMID:23712962
NQO1increases expressionISONqo1 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased expression of NQO1 mRNAPMID:11323195 PMID:17069994 PMID:18203689 PMID:23273579
NQO1multiple interactionsISONqo1 (Mus musculus)6480464CTDArsenic promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]; Cadmium promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]; Chromium inhibits the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Chromium inhibits the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]PMID:15337587
NQO1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTD[protocatechuic acid co-treated with Methylcholanthrene] results in increased activity of NQO1 protein; Buthionine Sulfoximine promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Ethoxyquin promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Buthionine Sulfoximine results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Ethoxyquin results in increased activity of NQO1 protein]; Methylcholanthrene results in increased expression of and results in increased activity of NQO1 proteinPMID:15302093 PMID:16906435 PMID:18203689
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