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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NQO1decreases activityISONqo1 (Rattus norvegicus)25823192RGDThioacetamide decreases activity of Nqo1 protein in liver 
NQO1decreases expressionISONqo1 (Rattus norvegicus)15090820RGDthioacetamide decreases expression of Nqo1 protein in rat liver 
NQO1decreases expressionISONqo1 (Rattus norvegicus)6480464CTDThioacetamide results in decreased expression of NQO1 proteinPMID:30295103
NQO1increases expressionISONqo1 (Rattus norvegicus)6480464CTDThioacetamide results in increased expression of NQO1 mRNAPMID:15976192 PMID:16337175 PMID:23411599 PMID:25242409 PMID:37008694
NQO1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of NQO1 mRNA; Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]; Verapamil inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]]PMID:23830814 PMID:28943392 PMID:30295103
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