Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDMercuric Chloride results in increased expression of NQO1 mRNA

PMID:21843634, PMID:26272509, PMID:27188386
multiple interactionsEXP 6480464CTD[NOG protein co-treated with Mercuric Chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO1 mRNA, Mercuric Chloride promotes the reaction [sulforafan results in increased expression of and results in increased activity of NQO1 protein], Mercuric Chloride promotes the reaction [sulforafan results in increased expression of NQO1 mRNA], Mercuric Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of NQO1 protein], Mercuric Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], Mercuric Chloride results in increased expression of and results in increased activity of NQO1 protein, NFE2L2 mRNA affects the reaction [Mercuric Chloride results in increased activity of NQO1 protein], NFE2L2 mRNA affects the reaction [Mercuric Chloride results in increased expression of NQO1 mRNA]

PMID:21843634, PMID:27188386
decreases expressionISORGD:104736480464CTDMercuric Chloride results in decreased expression of NQO1 mRNA

PMID:23202902
increases activityISORGD:104736480464CTDMercuric Chloride results in increased activity of NQO1 protein

PMID:18838692
multiple interactionsISORGD:104736480464CTD[Dimercaprol co-treated with Mercuric Chloride] results in increased activity of NQO1 protein

PMID:18838692
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.