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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of NQO1 protein

PMID:22155346, PMID:25419056, PMID:27561292, PMID:29260515
decreases response to substanceEXP 6480464CTDNQO1 protein results in decreased susceptibility to Arsenic Trioxide

PMID:20707922
increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of NQO1 mRNA, Arsenic Trioxide results in increased expression of NQO1 protein

PMID:19417148, PMID:22155346, PMID:23426167, PMID:24356939, PMID:25003661, PMID:25424538, PMID:27829220, PMID:29876539
multiple interactionsEXP 6480464CTD[Resveratrol co-treated with Arsenic Trioxide] results in increased expression of NQO1 protein, Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of NQO1 protein], allicin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein], MIR155 mRNA inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein], NFE2L2 protein promotes the reaction [Arsenic Trioxide results in increased expression of NQO1 protein], Tretinoin inhibits the reaction [Arsenic Trioxide results in increased expression of NQO1 protein]

PMID:25003661, PMID:27561292, PMID:29260515, PMID:29876539
decreases expressionISORGD:104736480464CTDArsenic Trioxide results in decreased expression of NQO1 mRNA

PMID:21533816
increases expressionISORGD:104736480464CTDArsenic Trioxide results in increased expression of NQO1 mRNA, Arsenic Trioxide results in increased expression of NQO1 protein

PMID:26187899, PMID:29049341
multiple interactionsISORGD:104736480464CTD[Arsenic Trioxide co-treated with Grape Seed Proanthocyanidins] results in increased expression of NQO1 mRNA, Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 mRNA], Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NQO1 mRNA], Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NQO1 protein], Arsenic Trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]], Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NQO1 mRNA], Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NQO1 protein], NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of NQO1 mRNA]

PMID:16274885, PMID:21533816, PMID:25815309, PMID:25966753, PMID:26187899, PMID:29049341
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.