Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:30314
Term: (R)-lipoic acid
Definition: The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDThioctic Acid results in increased activity of NQO1 protein

PMID:17940886
increases expressionEXP 6480464CTDThioctic Acid results in increased expression of NQO1 mRNA

PMID:17940886, PMID:19033392, PMID:23649336
multiple interactionsEXP 6480464CTD[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA, [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein

PMID:23649336
increases activityISORGD:25036480464CTDThioctic Acid results in increased activity of NQO1 protein

PMID:12180195
increases expressionISORGD:25036480464CTDThioctic Acid results in increased expression of NQO1 mRNA, Thioctic Acid results in increased expression of NQO1 protein

PMID:12180195
multiple interactionsISORGD:25036480464CTD[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA, Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]

PMID:23830814, PMID:31068541
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.