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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDNQO1 gene polymorphism affects the susceptibility to sodium arsenite

PMID:25395496
decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of NQO1 protein

PMID:27459794
increases expressionEXP 6480464CTDsodium arsenite results in increased expression of NQO1 mRNA, sodium arsenite results in increased expression of NQO1 protein

PMID:12377979, PMID:12426128, PMID:17409708, PMID:18417180, PMID:20100676, PMID:20473585, PMID:20805060, PMID:20886546, PMID:21281968, PMID:21776218, PMID:22714537, PMID:23699174, PMID:23738048, PMID:23876855, PMID:24161444, PMID:24516582, PMID:25493608, PMID:26039680, PMID:26535918, PMID:26878773, PMID:27413109, PMID:28125038, PMID:28229933, PMID:28713220
multiple interactionsEXP 6480464CTD[sodium arsenite co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 mRNA, [sodium arsenite co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 protein, Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to NQO1 promoter]], NFE2L1 protein affects the reaction [sodium arsenite results in increased expression of NQO1 mRNA], NFE2L2 mutant form inhibits the reaction [sodium arsenite results in increased expression of NQO1 protein], NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA], sodium arsenite promotes the reaction [NFE2L1 protein binds to NQO1 promoter], sodium arsenite promotes the reaction [NFE2L2 protein binds to NQO1 promoter], SQSTM1 protein promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA]

PMID:20805060, PMID:24161444, PMID:26878773, PMID:28125038, PMID:30309986
increases activityISORGD:104736480464CTDsodium arsenite results in increased activity of NQO1 protein

PMID:11979426, PMID:16274885, PMID:18838692
increases expressionISORGD:104736480464CTDsodium arsenite results in increased expression of NQO1 mRNA, sodium arsenite results in increased expression of NQO1 protein

PMID:11979426, PMID:16274885, PMID:16517059, PMID:16785233, PMID:21396911, PMID:22535251, PMID:26371860, PMID:27165637, PMID:27723467, PMID:28549828
multiple interactionsISORGD:104736480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in decreased expression of NQO1 mRNA, Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]], Acetylcysteine inhibits the reaction [sodium arsenite results in increased activity of NQO1 protein], Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of NQO1 mRNA], Ascorbic Acid promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA], Buthionine Sulfoximine inhibits the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]], Buthionine Sulfoximine inhibits the reaction [sodium arsenite results in increased activity of NQO1 protein], Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA], NFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased expression of NQO1 mRNA], Plant Extracts inhibits the reaction [sodium arsenite results in increased expression of NQO1 protein], sodium arsenite promotes the reaction [[NFE2L2 protein binds to MAFG protein] which binds to NQO1 promoter], sodium arsenite promotes the reaction [[NFE2L2 protein binds to MAFK protein] which binds to NQO1 promoter], sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein], sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of NQO1 protein], sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], sodium arsenite results in increased expression of and results in increased activity of NQO1 protein

PMID:16274885, PMID:16517059, PMID:16785233, PMID:22535251, PMID:27723467, PMID:28549828, PMID:31238026
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.