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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:2825
Term: aristolochic acid
Definition: A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chemical ID: MESH:C000228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:25036480464CTDaristolochic acid I results in increased activity of NQO1 protein

PMID:25209566
increases expressionISORGD:104736480464CTDaristolochic acid I results in increased expression of NQO1 mRNA, aristolochic acid I results in increased expression of NQO1 protein

PMID:25230394, PMID:27557898
increases expressionISORGD:25036480464CTDaristolochic acid I results in increased expression of NQO1 mRNA

PMID:17483316
multiple interactionsISORGD:104736480464CTD[Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I, [Dicumarol results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolite, [methyl 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oate co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA, [methyl 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oate co-treated with aristolochic acid I] results in increased expression of NQO1 protein, [Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I, [Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolite

PMID:21613233, PMID:24530882
multiple interactionsISORGD:25036480464CTD[1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA, [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of NQO1 protein, [aristolochic acid I co-treated with aristolochic acid II] results in increased expression of NQO1 mRNA

PMID:23912714, PMID:26845733
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.