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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:27641
Term: cycloheximide
Definition: A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.
Chemical ID: MESH:D003513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:104736480464CTDCycloheximide results in decreased expression of NQO1 mRNA

PMID:16243960, PMID:18474416
multiple interactionsISORGD:104736480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Lead results in increased expression of NQO1 mRNA]], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide promotes the reaction [Copper results in decreased expression of NQO1 mRNA]], Cycloheximide inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA], Cycloheximide inhibits the reaction [arsenite results in increased expression of NQO1 mRNA], Cycloheximide inhibits the reaction [Cadmium results in increased expression of NQO1 mRNA], Cycloheximide inhibits the reaction [Lead results in increased expression of NQO1 mRNA], Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA], Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], Cycloheximide promotes the reaction [Chromium results in increased expression of NQO1 mRNA], Cycloheximide promotes the reaction [Copper results in decreased expression of NQO1 mRNA]

PMID:14510636, PMID:16243960, PMID:18474416
multiple interactionsISORGD:25036480464CTDCycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]

PMID:24437944
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.