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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of NQO1 mRNA

PMID:25697376
multiple interactionsEXP 6480464CTD9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of and results in increased activity of NQO1 protein, Metformin inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of and results in increased activity of NQO1 protein], Metformin inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of NQO1 mRNA]

PMID:25697376
decreases expressionISORGD:25036480464CTD9, 10-Dimethyl-1, 2-benzanthracene results in decreased expression of NQO1 mRNA, 9, 10-Dimethyl-1, 2-benzanthracene results in decreased expression of NQO1 protein

PMID:24995432
increases activityISORGD:104736480464CTD9, 10-Dimethyl-1, 2-benzanthracene results in increased activity of NQO1 protein

PMID:18694800
multiple interactionsISORGD:104736480464CTDresveratrol inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased activity of NQO1 protein]

PMID:18694800
multiple interactionsISORGD:25036480464CTDtangeretin inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in decreased expression of NQO1 mRNA], tangeretin inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in decreased expression of NQO1 protein]

PMID:24995432
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.