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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:24814
Term: indole-3-methanol
Definition: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Chemical ID: MESH:C016517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:25036480464CTDindole-3-carbinol affects the expression of NQO1 mRNA

PMID:21396975
increases activityISORGD:25036480464CTDindole-3-carbinol results in increased activity of NQO1 protein

PMID:11446830
increases expressionISORGD:104736480464CTDindole-3-carbinol results in increased expression of NQO1 protein

PMID:11309284
increases expressionISORGD:25036480464CTDindole-3-carbinol results in increased expression of NQO1, indole-3-carbinol results in increased expression of NQO1 mRNA

PMID:21203749, PMID:24418717, PMID:9806166
multiple interactionsISORGD:104736480464CTDindole-3-carbinol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 protein]

PMID:29775573
multiple interactionsISORGD:25036480464CTD[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA, [indole-3-carbinol co-treated with Phenobarbital] results in increased expression of NQO1 mRNA, Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA]

PMID:22129741, PMID:24418717
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.