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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDCadmium results in increased activity of NQO1 protein

PMID:21172416
increases expressionEXP 6480464CTDCadmium results in increased expression of NQO1 mRNA, Cadmium results in increased expression of NQO1 protein

PMID:21172416
multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 mRNA

PMID:29741670
increases activityISORGD:104736480464CTDCadmium results in increased activity of NQO1 protein

PMID:15337587, PMID:18474416
increases activityISORGD:25036480464CTDCadmium results in increased activity of NQO1 protein

PMID:17573173
increases degradationISORGD:104736480464CTDCadmium results in increased degradation of NQO1 mRNA

PMID:18474416
increases expressionISORGD:104736480464CTDCadmium results in increased expression of NQO1 mRNA

PMID:15337587, PMID:16517059, PMID:18474416
increases expressionISORGD:25036480464CTDCadmium results in increased expression of NQO1 protein

PMID:22008531
multiple interactionsISORGD:104736480464CTDCadmium inhibits the reaction [beta-Naphthoflavone results in increased expression of NQO1 mRNA], Cadmium promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], Cadmium promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA], Cadmium promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein], Cadmium promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], Cycloheximide inhibits the reaction [Cadmium results in increased expression of NQO1 mRNA]

PMID:10972992, PMID:15337587, PMID:18474416
multiple interactionsISORGD:25036480464CTDAscorbic Acid promotes the reaction [Cadmium results in increased expression of NQO1 protein]

PMID:22008531
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.