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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:17183
Term: sanguinarine
Definition: A botanical anti-fungal agent that has formula C20H14NO4.
Chemical ID: MESH:C005705
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDsanguinarine results in decreased expression of NQO1 mRNA, sanguinarine results in decreased expression of NQO1 protein

PMID:22021338
decreases expressionISORGD:25036480464CTDsanguinarine results in decreased expression of NQO1 mRNA, sanguinarine results in decreased expression of NQO1 protein

PMID:24300172
increases reductionISORGD:25036480464CTDNQO1 protein results in increased reduction of sanguinarine

PMID:24300172
multiple interactionsISORGD:25036480464CTDNQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA], NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein], NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA], NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein]

PMID:24300172
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.