RGD Gene Chemical Interaction Report

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	735868
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	NQO1
Name:	NAD(P)H quinone dehydrogenase 1

Acc ID:	CHEBI:16494
Term:	lipoic acid
Definition:	A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
Chemical ID:	MESH:D008063

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	EXP		6480464	CTD	Thioctic Acid results in increased activity of NQO1 protein	PMID:17940886
increases expression	EXP		6480464	CTD	Thioctic Acid results in increased expression of NQO1 mRNA	PMID:17940886, PMID:19033392, PMID:23649336
multiple interactions	EXP		6480464	CTD	[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA, [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein	PMID:23649336
increases activity	ISO	RGD:2503	6480464	CTD	Thioctic Acid results in increased activity of NQO1 protein	PMID:12180195
increases expression	ISO	RGD:2503	6480464	CTD	Thioctic Acid results in increased expression of NQO1 mRNA, Thioctic Acid results in increased expression of NQO1 protein	PMID:12180195
multiple interactions	ISO	RGD:2503	6480464	CTD	[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA, Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]	PMID:23830814, PMID:31068541

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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