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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NQO1multiple interactionsISONqo1 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA]; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of NQO1 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA; NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of NQO1 mRNA]; oltipraz promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA]PMID:18488193 PMID:20350562 PMID:28163111
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