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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:104736480464CTD3, 4, 5, 3', 4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA], [Choline deficiency co-treated with Methionine deficiency] results in increased expression of NQO1 mRNA, [Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA, NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of NQO1 mRNA], oltipraz promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA]

PMID:18488193, PMID:20350562, PMID:28163111
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.