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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735826
Species: Homo sapiens
RGD Object: Gene
Symbol: GAST
Name: gastrin
Acc ID: CHEBI:18295
Term: histamine
Definition: A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID: MESH:D006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects abundanceISORGD:106206480464CTDGAST protein affects the abundance of Histamine

PMID:12893847
affects activityISORGD:106206480464CTDHistamine affects the activity of GAST protein

PMID:12893847
increases secretionISORGD:26626480464CTDGAST protein modified form results in increased secretion of Histamine, GAST protein results in increased secretion of Histamine

PMID:10864877, PMID:11164953, PMID:14642791, PMID:2470453
multiple interactionsISORGD:26626480464CTD[fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine], alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine], Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine], CXCL8 protein inhibits the reaction [GAST protein results in increased secretion of Histamine], Dinoprostone inhibits the reaction [GAST protein results in increased secretion of Histamine], Galanin inhibits the reaction [GAST protein results in increased secretion of Histamine], Impromidine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine], Misoprostol inhibits the reaction [GAST protein results in increased secretion of Histamine], Pentobarbital inhibits the reaction [GAST protein results in increased secretion of Histamine], SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine], TNF protein inhibits the reaction [GAST protein results in increased secretion of Histamine], Urethane inhibits the reaction [GAST protein results in increased secretion of Histamine]

PMID:10864877, PMID:11164953, PMID:12190085, PMID:16378173, PMID:2470453
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.