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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735819
Species: Homo sapiens
RGD Object: Gene
Symbol: TG
Name: thyroglobulin
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TGincreases expressionEXP 6480464CTDvorinostat results in increased expression of TG mRNAPMID:26751190
TGmultiple interactionsEXP 6480464CTDBRAF protein mutant form affects the reaction [vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TG mRNA]]; vorinostat affects the reaction [[BRAF protein mutant form affects the susceptibility to vemurafenib] which affects the expression of TG mRNA]; vorinostat affects the reaction [[TSHB protein co-treated with vemurafenib] affects the expression of TG mRNA]PMID:26751190
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