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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735784
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL3
Name: C-C motif chemokine ligand 3
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL3increases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL3 mRNAPMID:30768972
CCL3increases secretionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of CCL3 proteinPMID:30768972
CCL3multiple interactionsEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL3 mRNA]; 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of CCL3 protein]PMID:30768972
CCL3increases expressionISOCcl3 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL3 mRNAPMID:24378064
CCL3multiple interactionsISOCcl3 (Mus musculus)6480464CTDSunphenon inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL3 mRNA]PMID:24378064
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