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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735784
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL3
Name: C-C motif chemokine ligand 3
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL3decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of CCL3 mRNAPMID:22777745
CCL3increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CCL3 mRNA; Lipopolysaccharides results in increased expression of CCL3 proteinPMID:12818968 PMID:15263833 PMID:17529908 PMID:21147091 PMID:21352583 PMID:24707119 PMID:27568862 PMID:35811015
CCL3increases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of CCL3 proteinPMID:15289356 PMID:18390722 PMID:19211157 PMID:21913898 PMID:28065790 PMID:32800949
CCL3multiple interactionsEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL3 mRNA]; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL3 mRNA; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CCL3 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of CCL3 mRNA; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]PMID:12818968 PMID:15263833 PMID:19211157 PMID:21147091 PMID:21913898 PMID:27568862 PMID:30768972 PMID:35811015
CCL3increases expressionISOCcl3 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CCL3 mRNA; Lipopolysaccharides results in increased expression of CCL3 proteinPMID:10027076 PMID:10223745 PMID:10975854 PMID:11818323 PMID:16880258 PMID:19133137 PMID:21284090 PMID:21356202 PMID:22210036 PMID:25843059 PMID:25890327 PMID:26582142 PMID:27170112 PMID:27339419 PMID:27568862 PMID:9863660
CCL3increases expressionISOCcl3 (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of CCL3; Lipopolysaccharides results in increased expression of CCL3 mRNA; Lipopolysaccharides results in increased expression of CCL3 proteinPMID:21362633 PMID:21803157 PMID:22939914
CCL3increases secretionISOCcl3 (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of CCL3 proteinPMID:19339665 PMID:24056979 PMID:24561310 PMID:27984176 PMID:9863660
CCL3increases secretionISOCcl3 (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased secretion of CCL3 proteinPMID:22971837
CCL3multiple interactionsISOCcl3 (Mus musculus)6480464CTD3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; 5-aminoisoquinolinone inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of CCL3 mRNA; [Quercetin co-treated with Lipopolysaccharides] affects the expression of CCL3 mRNA; [Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of CCL3 mRNA; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL3 protein]; Cathelicidins inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of CCL3 mRNA]; coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; Cyclic AMP inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; IL6 protein affects the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Lipopolysaccharides results in increased expression of and results in increased secretion of CCL3 protein; luteolin 3'-glucuronide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; luteolin-7-O-glucuronide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; PARP1 protein affects the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; PARP1 protein affects the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Propranolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Propranolol promotes the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; Rolipram inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Rolipram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; terameprocol affects the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]PMID:11818323 PMID:15804595 PMID:16880258 PMID:19133137 PMID:19339665 PMID:20579867 PMID:21284090 PMID:21731756 PMID:22210036 PMID:24056979 PMID:24561310 PMID:25843059 PMID:26918785 PMID:27170112 PMID:27568862 PMID:27984176 PMID:9863660
CCL3multiple interactionsISOCcl3 (Rattus norvegicus)6480464CTDADM protein inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; CALCA protein inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; VCE-003 inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]PMID:21803157 PMID:22971837
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