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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735760
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF3
Name: activating transcription factor 3
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF3increases expressionEXP 6480464CTDAcrolein results in increased expression of ATF3 mRNAPMID:32530271
ATF3multiple interactionsEXP 6480464CTDAcrolein results in increased expression of and affects the localization of ATF3 protein; ALB protein inhibits the reaction [Acrolein results in increased expression of ATF3 mRNA]; Phenylbutyrates inhibits the reaction [Acrolein results in increased expression of ATF3 protein]PMID:18951912 PMID:32530271
ATF3increases expressionISOAtf3 (Rattus norvegicus)6480464CTDAcrolein results in increased expression of ATF3 mRNA; Acrolein results in increased expression of ATF3 proteinPMID:28119953
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