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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735748
Species: Mus musculus
RGD Object: Gene
Symbol: Snca
Name: synuclein, alpha
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sncaincreases expressionEXP 6480464CTDsodium arsenite results in increased expression of SNCA proteinPMID:27413109
Sncaaffects localizationISOSnca (Rattus norvegicus)6480464CTDsodium arsenite affects the localization of SNCA proteinPMID:17681577
Sncadecreases expressionISOSnca (Rattus norvegicus)6480464CTDsodium arsenite results in decreased expression of SNCAPMID:25639566
Sncaincreases expressionISOSNCA (Homo sapiens)6480464CTDsodium arsenite results in increased expression of SNCA mRNAPMID:22714537
Sncamultiple interactionsISOSnca (Rattus norvegicus)6480464CTDATG7 mutant form inhibits the reaction [sodium arsenite results in decreased expression of SNCA]; Melatonin inhibits the reaction [sodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]]; sodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]PMID:17645694 PMID:25639566
Sncamultiple interactionsISOSNCA (Homo sapiens)6480464CTDsodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]PMID:27413109
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