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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735742
Species: Mus musculus
RGD Object: Gene
Symbol: Ccnb1
Name: cyclin B1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnb1affects expressionEXP 6480464CTDCadmium Chloride affects the expression of CCNB1 mRNA; Cadmium Chloride affects the expression of CCNB1 proteinPMID:29287790
Ccnb1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of CCNB1 mRNAPMID:15501611 PMID:20061341
Ccnb1multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CCNB1 mRNA; [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCNB1 mRNAPMID:12135628 PMID:35134237
Ccnb1decreases expressionISOCcnb1 (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of CCNB1 mRNA; Cadmium Chloride results in decreased expression of CCNB1 proteinPMID:16730872 PMID:25993096
Ccnb1increases expressionISOCCNB1 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of CCNB1 proteinPMID:26385184
Ccnb1multiple interactionsISOCCNB1 (Homo sapiens)6480464CTD[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCNB1 protein; GJA1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCNB1 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein]PMID:26385184 PMID:28176351
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