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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735741
Species: Homo sapiens
RGD Object: Gene
Symbol: TIMP3
Name: TIMP metallopeptidase inhibitor 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TIMP3decreases expressionEXP 6480464CTDEstradiol results in decreased expression of TIMP3 mRNAPMID:16474171 PMID:19167446 PMID:19619570 PMID:21185374 PMID:23373633
TIMP3multiple interactionsEXP 6480464CTD[Estradiol binds to ESR2 protein] which results in increased expression of TIMP3 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of TIMP3 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIMP3 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of TIMP3 mRNAPMID:19619570 PMID:20226447 PMID:20404318 PMID:20660070
TIMP3affects expressionISOTimp3 (Rattus norvegicus)6480464CTDEstradiol affects the expression of TIMP3 mRNAPMID:32145629
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