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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A2decreases activityEXP 6480464CTDPhenobarbital results in decreased activity of CYP1A2 proteinPMID:19909766
CYP1A2increases activityEXP 6480464CTDPhenobarbital results in increased activity of CYP1A2 proteinPMID:19118567
CYP1A2increases expressionEXP 6480464CTDPhenobarbital results in increased expression of CYP1A2 mRNA; Phenobarbital results in increased expression of CYP1A2 proteinPMID:19118567 PMID:22258563 PMID:22310298 PMID:28541575
CYP1A2multiple interactionsEXP 6480464CTD[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA; Meclizine inhibits the reaction [[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of CYP1A2 mRNA]PMID:15272053
CYP1A2affects expressionISOCyp1a2 (Mus musculus)6480464CTDPhenobarbital affects the expression of CYP1A2 mRNAPMID:23091169
CYP1A2decreases expressionISOCyp1a2 (Rattus norvegicus)6480464CTDPhenobarbital results in decreased expression of CYP1A2 mRNA; Phenobarbital results in decreased expression of CYP1A2 proteinPMID:11328961 PMID:15596064 PMID:17381134 PMID:20607812 PMID:24090815 PMID:30842367
CYP1A2increases activityISOCyp1a2 (Mus musculus)6480464CTDPhenobarbital results in increased activity of CYP1A2 proteinPMID:10064569
CYP1A2increases expressionISOCyp1a2 (Mus musculus)6480464CTDPhenobarbital results in increased expression of CYP1A2 mRNA; Phenobarbital results in increased expression of CYP1A2 proteinPMID:10064569 PMID:16109766 PMID:17962186 PMID:18692084 PMID:20403969 PMID:23681119 PMID:28218408 PMID:28541575 PMID:30503582 PMID:32320717 PMID:9397191
CYP1A2increases expressionISOCyp1a2 (Rattus norvegicus)6480464CTDPhenobarbital results in increased expression of CYP1A2 mRNAPMID:20226384 PMID:23273579 PMID:24449422 PMID:8849338
CYP1A2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Phenobarbital co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; ciprofibrate inhibits the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA]; MED1 protein promotes the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA]; NR1I3 gene mutant form inhibits the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA]; pirinixic acid inhibits the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA]PMID:16109766 PMID:17962186 PMID:23681119 PMID:28218408
CYP1A2multiple interactionsISOCyp1a2 (Rattus norvegicus)6480464CTD[Phenobarbital co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 protein; Choline deficiency promotes the reaction [Phenobarbital results in increased expression of CYP1A2 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]PMID:18486174 PMID:18798224 PMID:30842367
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