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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Acc ID: CHEBI:8050
Term: phenacetin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group.
Chemical ID: MESH:D010615
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A2affects metabolic processingEXP 6480464CTDCYP1A2 protein affects the metabolism of PhenacetinPMID:11751525 PMID:15801540 PMID:3577206
CYP1A2decreases ethylationEXP 6480464CTDCYP1A2 protein results in decreased ethylation of PhenacetinPMID:11303964 PMID:12433797 PMID:14563787 PMID:14725854 PMID:15618748 PMID:8020169
CYP1A2increases activityEXP 6480464CTDPhenacetin results in increased activity of CYP1A2 proteinPMID:15802386
CYP1A2increases metabolic processingEXP 6480464CTDCYP1A2 protein results in increased metabolism of PhenacetinPMID:12401345 PMID:12467917 PMID:15043991 PMID:15155557 PMID:15370959 PMID:16049126 PMID:16124035 PMID:17267297 PMID:17418993 PMID:17702393 PMID:19135037 PMID:21915887 PMID:23850985 PMID:27939613 PMID:28119166 PMID:28762043 PMID:31706005 PMID:35366062 PMID:35748891
CYP1A2increases oxidationEXP 6480464CTDCYP1A2 protein results in increased oxidation of Phenacetin; CYP1A2 protein results in increased oxidation of Phenacetin analogPMID:10985777 PMID:11284709 PMID:18032064 PMID:19053182 PMID:9195021
CYP1A2multiple interactionsEXP 6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [CYP1A2 protein results in decreased ethylation of Phenacetin]; 2-aminofluorene inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; 4-amino-2-phenoxymethanesulfonanilide promotes the reaction [CYP1A2 protein results in increased oxidation of Phenacetin]; 8-phenyltheophylline inhibits the reaction [CYP1A2 protein results in decreased ethylation of Phenacetin]; [5-bromotryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-chlorotryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-fluorotryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [5-methyltryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [7-methyltryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [alpha-naphthoflavone results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Amiodarone results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [CYP1A2 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [indopan analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [indopan results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Methoxydimethyltryptamines analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [N,N-diisopropyltryptamine analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; [Tryptamines analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; CYP1A2 protein results in increased oxidation of and results in decreased ethylation of Phenacetin; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; furafylline inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; O(6)-benzylguanine inhibits the reaction [CYP1A2 protein affects the metabolism of Phenacetin]; obeticholic acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; Oleanolic Acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; zileuton inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]PMID:11465391 PMID:11751525 PMID:14570767 PMID:15043991 PMID:16049126 PMID:19053182 PMID:19135037 PMID:21915887 PMID:22524704 PMID:23850985 PMID:26599973 PMID:27939613 PMID:28119166 PMID:29445054 PMID:31706005 PMID:35366062 PMID:35748891 PMID:8020169
CYP1A2affects metabolic processingISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 protein affects the metabolism of PhenacetinPMID:15742976
CYP1A2affects metabolic processingISOCyp1a2 (Rattus norvegicus)6480464CTDCYP1A2 protein affects the metabolism of PhenacetinPMID:15231049 PMID:15801540 PMID:15879494
CYP1A2decreases ethylationISOCyp1a2 (Rattus norvegicus)6480464CTDCYP1A2 protein results in decreased ethylation of PhenacetinPMID:11911841 PMID:12064368
CYP1A2increases expressionISOCyp1a2 (Mus musculus)6480464CTDPhenacetin results in increased expression of CYP1A2 proteinPMID:15742976
CYP1A2increases metabolic processingISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 protein results in increased metabolism of PhenacetinPMID:10445756 PMID:30503582
CYP1A2increases metabolic processingISOCyp1a2 (Rattus norvegicus)6480464CTDCYP1A2 protein results in increased metabolism of PhenacetinPMID:12222751 PMID:17651725 PMID:28438436 PMID:8905919
CYP1A2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[CYP1A2 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen; Phenacetin inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens]PMID:1567206 PMID:30503582
CYP1A2multiple interactionsISOCyp1a2 (Rattus norvegicus)6480464CTD[CYP1A2 protein results in increased metabolism of Phenacetin] which results in increased chemical synthesis of Acetaminophen; Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]; Norfloxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]PMID:28438436 PMID:8905919
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