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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Acc ID: CHEBI:77260
Term: 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole
Definition: A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Chemical ID: MESH:D009853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A2decreases activityEXP 6480464CTDOmeprazole results in decreased activity of CYP1A2 proteinPMID:16035375
CYP1A2increases activityEXP 6480464CTDOmeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 proteinPMID:18502397 PMID:19118567 PMID:19230594 PMID:23274770 PMID:36288780
CYP1A2increases expressionEXP 6480464CTDOmeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 proteinPMID:12040753 PMID:12623754 PMID:12841937 PMID:15681896 PMID:15802389 PMID:17954527 PMID:18332078 PMID:19118567 PMID:19230594 PMID:20171196 PMID:21784029 PMID:21924250 PMID:22524704 PMID:23274770 PMID:23850985 PMID:24752503 PMID:26204831 PMID:27794450 PMID:36288780 PMID:9744552
CYP1A2multiple interactionsEXP 6480464CTD[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 proteinPMID:15802389 PMID:20171196 PMID:22524704 PMID:31863871
CYP1A2decreases activityISOCyp1a2 (Mus musculus)6480464CTDOmeprazole results in decreased activity of CYP1A2 proteinPMID:18420780
CYP1A2increases expressionISOCyp1a2 (Rattus norvegicus)6480464CTDOmeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 proteinPMID:19118567 PMID:25626140 PMID:9152597
CYP1A2multiple interactionsISOCyp1a2 (Rattus norvegicus)6480464CTD[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNAPMID:22687989
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