Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Acc ID: CHEBI:1367
Term: 3,3',4,4'-tetrachlorobiphenyl
Definition: A tetrachlorobiphenyl that is biphenyl in which the hydrogens at position 3 and 4 on each phenyl group are replaced by chlorines.
Chemical ID: MESH:C028451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A2increases expressionEXP 6480464CTD3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A2 proteinPMID:31733235
CYP1A2decreases response to substanceISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 results in decreased susceptibility to 3,4,3',4'-tetrachlorobiphenylPMID:21571617
CYP1A2increases expressionISOCyp1a2 (Mus musculus)6480464CTD3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A2 mRNAPMID:12117779 PMID:19467301
CYP1A2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD3,4,3',4'-tetrachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]PMID:20961953
CYP1A2multiple interactionsISOCyp1a2 (Rattus norvegicus)6480464CTD3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [CYP1A2 protein results in decreased methylation of 7-methoxyresorufin]PMID:12635099
Go Back to source page   Continue to Ontology report