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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735707
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1A
Name: interleukin 1 alpha
Acc ID: CHEBI:49976
Term: zinc dichloride
Definition: A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.
Chemical ID: MESH:C016837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Aincreases expressionISOIl1a (Mus musculus)6480464CTDzinc chloride results in increased expression of IL1A proteinPMID:18509044
IL1Amultiple interactionsISOIl1a (Mus musculus)6480464CTDN-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1A protein]PMID:18509044
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