GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IL1A | decreases expression | EXP | | 6480464 | CTD | sodium arsenite results in decreased expression of IL1A mRNA | PMID:12679051 | IL1A | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of IL1A mRNA | PMID:20886546 PMID:24570342 PMID:26535918 PMID:34032870 | IL1A | multiple interactions | EXP | | 6480464 | CTD | 2,2'-Dipyridyl inhibits the reaction [sodium arsenite results in increased expression of IL1A mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [sodium arsenite results in increased expression of IL1A mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL1A mRNA]; LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of IL1A mRNA] | PMID:24570342 | IL1A | decreases expression | ISO | Il1a (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of IL1A mRNA | PMID:21911445 | IL1A | increases expression | ISO | Il1a (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of IL1A mRNA; sodium arsenite results in increased expression of IL1A protein | PMID:35364107 PMID:37682722 | IL1A | multiple interactions | ISO | Il1a (Mus musculus) | 6480464 | CTD | [sodium arsenite co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL1A protein; diacerein inhibits the reaction [[sodium arsenite co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL1A protein]; diacerein inhibits the reaction [sodium arsenite results in increased expression of IL1A protein]; GSK-2816126 promotes the reaction [sodium arsenite results in increased expression of IL1A mRNA]; GSK-2816126 promotes the reaction [sodium arsenite results in increased expression of IL1A protein]; sodium arsenite inhibits the reaction [EZH2 protein binds to IL1A 5' UTR]; sodium arsenite results in increased expression of and results in increased secretion of IL1A protein | PMID:35364107 | IL1A | multiple interactions | ISO | Il1a (Rattus norvegicus) | 6480464 | CTD | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IL1A protein]; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IL1A protein | PMID:35993674 | | ||||||||||||||||||||||
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