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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735707
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1A
Name: interleukin 1 alpha
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Amultiple interactionsEXP 6480464CTD[Acetylcysteine co-treated with IL1A protein] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [butylphen results in increased expression of IL1A protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1A protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of IL1A protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL1A mRNA]; Acetylcysteine promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of IL1A protein]]PMID:24570342 PMID:26138014 PMID:28836394 PMID:7476933
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