GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GCK | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of GCK mRNA | PMID:31121516 | GCK | affects expression | ISO | Gck (Rattus norvegicus) | 6480464 | CTD | bisphenol A affects the expression of GCK mRNA | PMID:32145629 | GCK | decreases expression | ISO | Gck (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in decreased expression of GCK mRNA | PMID:22946080 PMID:23328667 PMID:24793715 PMID:25181051 PMID:37570835 | GCK | increases expression | ISO | Gck (Mus musculus) | 6480464 | CTD | bisphenol A results in increased expression of GCK mRNA; bisphenol A results in increased expression of GCK protein | PMID:21932408 PMID:30566610 PMID:32156529 PMID:33221593 PMID:36674557 | GCK | increases methylation | ISO | Gck (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in increased methylation of GCK gene; bisphenol A results in increased methylation of GCK promoter | PMID:23748860 PMID:24793715 PMID:28505145 | GCK | multiple interactions | ISO | Gck (Rattus norvegicus) | 6480464 | CTD | [bisphenol A results in increased methylation of GCK promoter] which results in decreased expression of GCK mRNA; Resveratrol inhibits the reaction [bisphenol A results in decreased expression of GCK mRNA] | PMID:23748860 PMID:37570835 | |
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