GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gclm | affects expression | EXP | | 6480464 | CTD | Acetaminophen affects the expression of GCLM mRNA | PMID:17562736 | Gclm | affects response to substance | EXP | | 6480464 | CTD | GCLM protein affects the susceptibility to Acetaminophen | PMID:17584759 | Gclm | decreases expression | EXP | | 6480464 | CTD | Acetaminophen results in decreased expression of GCLM mRNA | PMID:25818464 PMID:29355602 PMID:30273691 | Gclm | decreases response to substance | EXP | | 6480464 | CTD | GCLM protein results in decreased susceptibility to Acetaminophen | PMID:18642143 | Gclm | increases expression | EXP | | 6480464 | CTD | Acetaminophen results in increased expression of GCLM mRNA; Acetaminophen results in increased expression of GCLM protein | PMID:18468992 PMID:25499718 PMID:29325178 PMID:33271250 PMID:33571619 PMID:37792503 | Gclm | multiple interactions | EXP | | 6480464 | CTD | [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLM mRNA; [GCLC protein binds to GCLM protein] which results in decreased susceptibility to Acetaminophen; Acetaminophen promotes the reaction [Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]]; andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA]; OGT gene mutant form promotes the reaction [Acetaminophen results in increased expression of GCLM mRNA]; SHP gene mutant form promotes the reaction [Acetaminophen results in increased expression of GCLM mRNA]; SHP gene mutant form promotes the reaction [Acetaminophen results in increased expression of GCLM protein]; sodium boranocarbonate affects the reaction [Acetaminophen results in decreased expression of GCLM mRNA]; sulforaphane inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA] | PMID:16840778 PMID:25818464 PMID:29325178 PMID:29355602 PMID:30273691 PMID:31697998 PMID:37792503 | Gclm | increases expression | ISO | Gclm (Rattus norvegicus) | 6480464 | CTD | Acetaminophen results in increased expression of GCLM mRNA | PMID:11245408 PMID:17202758 PMID:17202762 PMID:30723492 PMID:33387578 | Gclm | increases expression | ISO | GCLM (Homo sapiens) | 6480464 | CTD | Acetaminophen results in increased expression of GCLM mRNA; Acetaminophen results in increased expression of GCLM protein | PMID:21420995 PMID:29067470 PMID:29136249 PMID:30008028 PMID:37792503 | Gclm | multiple interactions | ISO | GCLM (Homo sapiens) | 6480464 | CTD | [Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in increased expression of GCLM mRNA; pyrazolanthrone inhibits the reaction [[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA]; SHP protein inhibits the reaction [Acetaminophen results in increased expression of GCLM protein] | PMID:25881548 PMID:33819548 PMID:37792503 | | ||||||||||||||||||||||
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