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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735691
Species: Mus musculus
RGD Object: Gene
Symbol: Gclm
Name: glutamate-cysteine ligase, modifier subunit
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclmincreases expressionISOGCLM (Homo sapiens)6480464CTDArsenic results in increased expression of GCLM mRNA; Arsenic results in increased expression of GCLM proteinPMID:18487201 PMID:19945496 PMID:27413109
Gclmmultiple interactionsISOGCLM (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLM mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLM protein; [Cacodylic Acid results in increased abundance of Arsenic] which results in increased expression of GCLM protein; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GCLM mRNA; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GCLM protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GCLM mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GCLM proteinPMID:32188015 PMID:32525701 PMID:33434570
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